Talk:Clonazepam

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CYP2C19

In 2011, this page was edited to note that clonazepam is metabolized by CYP2C19 as well as by CYP3A4. However, I've been unable to find any reliable non-Wikipedia sources for the claim that clonazepam is a CYP2C19 substrate. Conversely, several sources claim that clonazepam is primarily/exclusively a 3A4 substrate (Medscape, Drugbank), or that it is not affected by 2C19 inhibitors (Drugs.com).

The closest I've been able to find is an article in IJPBS called Genetic polymorphism of CYP2C19 in a sample of Iraqi population. However, this article was published in 2015 (long after this edit), and the journal does not seem particularly reputable. Further, the article's source for this claim is a 2001 article called Clinical relevance of genetic polymorphisms in the human CYP2C subfamily in BJCP, which does *not* list clonazepam as one of the CYP2C19-metabolized drugs. In other words, the authors might have been referring to Wikipedia when they wrote this sentence.

Does anyone have a good source for the existence of this metabolic pathway, that was clearly published _before_ Wikipedia was edited? If not, I think we should remove this claim. SashaMarievskaya (talk) 00:55, 3 January 2018 (UTC)[reply]

Okay, problem solved. Someone got "clobazam" and "clonazepam" confused. The questionable Wikipedia text is word-for-word identical to text from the Medscape article on clobazam.

I'm deleting the false claim. SashaMarievskaya (talk) 01:02, 3 January 2018 (UTC)[reply]

Actually, I spoke too quickly. The wording is not quite identical. However, I still think that the problem is a confusion between these two drugs, since clobazam is widely attested to be metabolized by CYP2C19, and clonazepam (the subject of this article) is not. If no one has any concerns in the next day or so, I'll remove the claim. SashaMarievskaya (talk) 01:08, 3 January 2018 (UTC)[reply]

Added ref to one[1] Doc James (talk · contribs · email) 07:08, 3 January 2018 (UTC)[reply]

Repetition

We say that it is used to treat seizures and panic disorder and movement disorders thus this "Clonazepam has anticonvulsant, anxiolytic, and muscle relaxant properties.^[1]^[2]^[3]^[4]" is not really needed. Doc James (talk · contribs · email) 00:38, 26 April 2018 (UTC)[reply]

References

^ Ashton, Dr. Heather (April 2007). "Benzodiazepine Equivalency Table". Retrieved 22 March 2015.
^ http://www.mental-health-today.com/rx/benzo.htm
^ http://www.bcnc.org.uk/equivalence.html
^ Benzo Equivalency Table| link= https://emedicine.medscape.com/article/2172250-overview#a1

Moved from article

I have moved the following content here because it lacks context/explanation. If anyone wants to use it to improve the article, here it is. -- Ed (Edgar181) 20:23, 23 September 2018 (UTC)[reply]

==Synthesis== [[File:Clonazepam synthesis.png|700px]]

Chronic pain

I think it would be helpful to add off-label use of clonazepam in chronic pain (neuroplastic pain) syndromes. It has some robust analgetic properties when used acutely in atypical facial pain, fibromyalgia, TMD and simillar disorders of central senzitization. Šaholjubac (talk) 22:11, 3 November 2023 (UTC)[reply]

[ashtontable-1] Ashton, Dr. Heather (April 2007). "Benzodiazepine Equivalency Table". Retrieved 22 March 2015.

[2] ttp://www.mental-health-today.com/rx/benzo.htm

[3] ttp://www.bcnc.org.uk/equivalence.html

[2-4] Benzo Equivalency Table| link= https://emedicine.medscape.com/article/2172250-overview#a1

[1]

[2]

[3]

[4]